gpcr/g protein — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21874	CID 2745687		GPR
	CID 2745687 is a GPR35 antagonist that inhibited the effects at human GPR35 of cromolyn disodium and zaprinast, two agonists that share an overlapping binding site.		GPR
T8329	AR 231453		GPR
	AR 231453 is a selective and orally available GPR119 agonist,can stimulate β-cell replication and improve islet graft function.		GPR
T10363	Arazine	N-Acetyl-S-farnesyl-L-cysteine	Others
	Arazine (N-Acetyl-S-farnesyl-L-cysteine) can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and G...		Others
T3433	TUG-891	TUG 891,TUG891	GPR
	TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.		GPR
T50088	N-phenylthiophene-2-carboximidamide		Others
	N-phenylthiophene-2-carboximidamide is a thiophene derivative that functions as an inhibitor of protein tyrosine kinases (PTKs) and a ligand for G protein-coupled receptors (GPCRs).		Others
T10843	CMF019		Apelin receptor
	CMF019 is a potent agonist of the Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ (pKis: 8.58, 8.49, and 8.71 for the human, rat, and mouse).		Apelin receptor
T9146	Ms48107	Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro-	Others
	MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch...		Others
T27428	GP-1681	GP 1681,GP1681
	GP-1681, a G-protein coupled receptor (GPCR) agonist, is used potentially for the treatment of influenza infection.
T26962	CBP-307	CBP307
	CBP-307 is a selective second generation S1P1 (a G-protein coupled receptor -GPCR) modulator.
T83743	VPM-p15 TFA	T1V/F3Phe(4-Me)
	VPM-p15, a synthetic peptide agonist targeting the adhesion G protein-coupled receptor (GPCR) G2 (ADGRG2)—an orphan GPCR implicated in male infertility—facilitates cAMP accumulation in HEK293 cells expressing human ADGRG...
T73005	PF-07054894
	PF-07054894 is a potent antagonist of the CCR6 and a targeted G protein-coupled receptor (GPCR), useful in the research of inflammatory bowel disease.
TN5580	Rediocide A
	Rediocide A, an insecticide, can inhibit calcium mobilization in Drosophila G-protein- coupled receptors (GPCR)s other than methuselah, it can induce GPCR desensitization and internalization, and such effects are mediate...
T63340	CCG-273220
	CCG-273220 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) (IC50: 220 nM).CCG-273220 covalently binds the GRK5 subfamily-specific residue Cys474 and is more selective for GRK5 than GRK2.
T81683	Neuromedin S (human)
	Neuromedin S (human) is a 33-amino acid neuropeptide identified as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1, acting on the neuromedin U (NMU) receptor 2 (NMUR2) to regulate body we...
T70468	MK-8666
	MK-8666 is a partial GPCR agonist that is coordinated with the action of GPR40. MK-8666 has been investigated for treatment of type 2 diabetes mellitus.
T69953	MK-8666 Tris
	MK-8666 Tris is a partial GPCR agonist that is coordinated with the action of GPR40. MK-8666 has been investigated for treatment of type 2 diabetes mellitus.
T36578	Boc-Lys(Ac)-AMC
	Commendamide (N-acyl-3-hydroxypalmitoyl-glycine) is a newly discovered GPCR G2A/GPR132 agonist (EC50=11.8 μM) that isolated from Bacteroides vulgatus. [1] G2A/GPR132 belongs to the guanine nucleotide-binding protein (G p...
T77789	Oleoyl-L-alpha-lysophosphatidic acid sodium salt	LPA sodium salt
	Oleoyl-L-alpha-lysophosphatidic acid sodium salt is an essential cell membrane biosynthetic metabolite that mediates signal transduction by interacting with G protein-coupled receptors (GPCRs) (ie, LPA receptors). It is ...
T36550	CAY10535
	TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucida...
T83926	S-Geranylgeranyl-L-glutathione	GGG
	S-Geranylgeranyl-L-glutathione acts as a ligand for the orphan G protein-coupled receptor (GPCR) P2RY8, displaying selective affinity by inducing internalization of P2RY8 in preference to the sphingosine-1-phosphate rece...